Specific immunity in mice to heartwater.
نویسنده
چکیده
Mice develop a specific immune response following infection with the mice strains of heartwater. In the case of the Kümm strain the agent can persist in some tissues for up to 365 days. Transfer of spleen cells from immune mice confers protection against homologous challenge in recipient mice showing that cell mediated immunity is important. A comparison with immune mechanisms occurring in other Rickettsia is discussed.
منابع مشابه
Specific immunity in farm animals to heartwater.
The duration of immunity to heartwater normally varies from 6 months to 4 years. In Angora goats it may be difficult to produce a specific immune response with vaccination. Humoral immunity does not appear to play a role in the development of immunity. It has been suggested that cellular immunity may play a role, but the actual mechanism involved remains obscure. The specific immune response de...
متن کاملDiagnosis of heartwater at post-mortem in ruminants and the confirmation of Cowdria ruminantium in mice.
Criteria that are required to confirm heartwater in ruminants and mice are discussed. In ruminants it entails the macroscopical and microscopical lesions as well as the identification of Cowdria ruminantium in brain smears or histological sections. Macroscopical lesions in the majority of animals that die of the disease include effusion of body cavities, hydropericardium, oedema of the lungs, b...
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This preliminary investigation confirmed that when Angora goats were immunized against heartwater, either when kids or young goats, they still had an immunity to heartwater a year later when they were challenged with a vaccine containing Cowdria ruminantium. An overwhelming majority of the uninoculated animals which were challenged at the same time were susceptible to clinical heartwater. Strat...
متن کاملThe Effect of Cationic Liposomes Encapsulating pcDNA3.1+PA Plasmids on Humoral Immune Response in Mice
Background: DNA vaccines are third generation vaccines which have made promises to combat infectious diseases. Cationic liposomes are used as effective delivery systems for DNA vaccines to generate stronger immunity. Objective: Encapsulation of pcDNA3.1+PA plasmid, encoding protective antigen (PA) of Bacillus anthracis (B. anthracis) into cationic liposomes, and evaluation of its effect on spec...
متن کاملHeartwater in Angora goats. I. Immunity subsequent to artificial infection and treatment.
This study confirmed reports that Angora goats are highly susceptible to Cowdria ruminantium and showed that immunization of this breed against heartwater may be difficult hazardous. It was found that if goats were treated on the 2nd or 3rd day of the febrile reaction following the intravenous inoculation of the heartwater agent, few animals survived the infection. If, on the other hand, treatm...
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ورودعنوان ژورنال:
- The Onderstepoort journal of veterinary research
دوره 54 3 شماره
صفحات -
تاریخ انتشار 1987